Article

Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain

2026-02-03

Abstract excerpt

<h4>SUMMARY</h4> Directly measuring chromatin states alongside transcription is essential for understanding how cell-type-specific regulatory programs are established and maintained in the adult human brain. We present a large-scale single-cell multimodal atlas generated by jointly profiling transcriptome with active (H3K27ac) and repressive (H3K27me3) histone modifications across 18 brain regions. We profile >75...

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Literature Corpus work: 3455361c-7064-5c51-839e-fdad2a41a780
DOI: 10.64898/2026.02.02.703166

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