Article
DeepLoop robustly maps chromatin interactions from sparse allele-resolved or single-cell Hi-C data at kilobase resolution.
Nature genetics - 1 Jul 2022
Zhang Shanshan, Plummer Dylan, Lu Leina, Cui Jian, Xu Wanying, Wang Miao, Liu Xiaoxiao, Prabhakar Nachiketh, Shrinet Jatin, Srinivasan Divyaa, Fraser Peter, Li Yan, Li Jing, Jin Fulai
Abstract excerpt
Mapping chromatin loops from noisy Hi-C heatmaps remains a major challenge. Here we present DeepLoop, which performs rigorous bias correction followed by deep-learning-based signal enhancement for robust chromatin interaction mapping from low-depth Hi-C data. DeepLoop enables loop-resolution, single-cell Hi-C analysis. It also achieves a cross-platform convergence between different Hi-C protocols and micrococcal...
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