Article

Microglia are necessary for toxin-mediated demyelination and activation of microglia is sufficient to induce demyelination

2018-12-19

Abstract excerpt

Microgliosis is a prominent pathological feature in many neurological diseases including multiple sclerosis (MS). The precise role of microglia during demyelination, and the relative contributions of microglia vs. peripheral macrophages, are incompletely understood. Here, using a genetic fate mapping strategy, we identify microglia as predominant responders and key effectors of demyelination in the cuprizone (CUP)...

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Literature Corpus work: d8e34113-ab7f-5ee3-8896-a415407aaf8e
DOI: 10.1101/501148

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