Article
Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration.
Acta neuropathologica - 1 Jun 2021
van Olst Lynn, Rodriguez-Mogeda Carla, Picon Carmen, Kiljan Svenja, James Rachel E, Kamermans Alwin, van der Pol Susanne M A, Knoop Lydian, Michailidou Iliana, Drost Evelien, Franssen Marc, Schenk Geert J, Geurts Jeroen J G, Amor Sandra, Mazarakis Nicholas D, van Horssen Jack, de Vries Helga E, Reynolds Richard, Witte Maarten E
Abstract excerpt
Meningeal inflammation strongly associates with demyelination and neuronal loss in the underlying cortex of progressive MS patients, thereby contributing significantly to clinical disability. However, the pathological mechanisms of meningeal inflammation-induced cortical pathology are still largely elusive. By extensive analysis of cortical microglia in post-mortem progressive MS tissue, we identified cortical...
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