Spinal Cord Microglia Exhibit Impaired Repair Responses to Myelin Damage

Abstract excerpt

<h4>Background</h4> Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that affects both the brain and spinal cord, although the brain has historically received greater attention. In the inducible, oligodendrocyte-specific knockout model of Myrf , which results in white matter damage to both the brain and spinal cord, our laboratory previously demonstrated that the brain under...

Topics

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• Demyelinating Diseases
• Disease Models, Animal
• Mice
• Mice, Inbred C57BL
• Microglia
• Myelin Sheath
• Nerve Fibers, Myelinated
• Nerve Regeneration

Identifiers and source

Literature Corpus work

83b208db-c63f-5250-ab39-febb64492c56

DOI

10.64898/2026.02.23.707565