Article

An inducible genetic tool for tracking and manipulating specific microglial states in development and disease

2023-12-04

Abstract excerpt

<h4>SUMMARY</h4> Recent single-cell RNA sequencing studies have revealed distinct microglial states in development and disease. These include proliferative region-associated microglia (PAM) in developing white matter and disease-associated microglia (DAM) prevalent in various neurodegenerative conditions. PAM and DAM share a similar core gene signature and other functional properties. However, the extent of the d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d0ab8025-52d5-5611-83c0-8c0728a57ae3
DOI: 10.1101/2023.12.01.569597

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An inducible genetic tool for tracking and manipulating specific microglial states in development and diseaseDOI 10.1101/2023.12.01.569597Read

Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencingSemantic proximity Read

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brainSemantic proximity Read

Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelinationSemantic proximity Read

A comparative analysis of microglial inducible Cre linesSemantic proximity Read

Single-cell Transcriptomics Analyses Revealed Specialized Microglial Subsets with Oligodendrocyte-like SignaturesSemantic proximity Read

Functional Mature Human Microglia Developed in Human iPSC Microglial Chimeric Mouse BrainSemantic proximity Read

Myeloid masquerade: Microglial transcriptional signatures in retinal development and diseaseSemantic proximity Read

Analyzing microglial phenotypes across neuropathologies: a practical guide.Semantic proximity Read

Spatial transcriptomics reveals heterogeneous cell–cell interactions among brain regions in a cuprizone model consistent with multiple sclerosis lesionsSemantic proximity Read

Dicer deficiency in microglia leads to accelerated demyelination and failed remyelinationSemantic proximity Read

Microglial plasticity governed by state-specific enhancer landscapesSemantic proximity Read

Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mappingSemantic proximity Read