Article

Soluble TREM2 induces microglia dysfunction and brain damage while cleavage-reduced TREM2 shows sustained microglia activation with enhanced remyelination in the cuprizone model

2022-03-25

Abstract excerpt

<title>Abstract</title> <p>Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts and monocytes/macrophages. In humans, homozygous loss-of-function mutation carriers exhibit bone cysts and fractures with an early-onset frontal lobe syndrome and progressive presenile dementia known as Nasu-Hakola. Neuropathological findings include myelin/neuro...

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Literature Corpus work: 36d62bf6-b52f-52ff-8d32-c6688d9b2870
DOI: 10.21203/rs.3.rs-1431273/v1

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