Article

C57BL6 mouse substrains demonstrate differences in susceptibility to the demyelinating effects of Cuprizone toxin

2020-12-18

Abstract excerpt

Advances in our understanding of cellular functions and phenotypes in the brain rely on technically robust experimental in vivo models with face validity towards human disease. The cuprizone toxin-induced demyelination model is widely used to investigate pathophysiological mechanisms of demyelinating and remyelinating phases of multiple sclerosis. The C57BL6 mouse is a common inbred strain used as the genetic bac...

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Literature Corpus work: 77d634df-c368-51d0-9c39-355259c83bb7
DOI: 10.1101/2020.12.17.423334

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