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Age-related loss of brain demyelinating and remyelinating potential is overcome by microglia renewal

2026-06-18

Abstract excerpt

Multiple sclerosis (MS) is an immune-mediated demyelinating disease, with progressive neurodegeneration that is refractory to current therapies. Here, we identify microglia aging as a major factor responsible for age-related loss of beneficial demyelinating and remyelinating brain functions. Brain transcriptomics and in situ spatial gene transcription analysis revealed significant oligodendrocyte loss in both youn...

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Literature Corpus work
61ba0cca-dc59-58f4-ac94-31fb2320ceec
DOI
10.64898/2026.06.15.732390
Open publication

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Age-related loss of brain demyelinating and remyelinating potential is overcome by microglia renewalDOI 10.64898/2026.06.15.732390
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