Article

A comparative transcriptomic analysis of mouse demyelination models and Multiple Sclerosis lesions

2025-03-25

Abstract excerpt

Demyelinating diseases are debilitating conditions characterized by loss of the myelin sheaths, ultimately leading to neurodegeneration. Toxicity models are among the most commonly used mouse models to induce demyelination; however, it remains unclear whether different demyelination models elicit distinct glial responses, and how comparable these changes are to human diseases like Multiple Sclerosis (MS). To addre...

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Identifiers and source

Literature Corpus work: 9097fe01-559e-5170-afd0-c9ccff37c580
DOI: 10.1101/2025.03.24.645058

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