Article

Genetically perturbed myelin as a risk factor for neuroinflammation-driven axon degeneration

2023-07-19

Abstract excerpt

Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. Here we study mice with distinct defects in the proteolipid protein 1 gene that develop axonal damage which is driven by cytotoxic T cells targeting myelina...

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Identifiers and source

Literature Corpus work: 1b822076-a86f-59c5-a6f6-e41abb4b0c42
DOI: 10.1101/2023.07.17.549427

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