Article

Spatial transcriptomics reveals heterogeneous cell–cell interactions among brain regions in a cuprizone model consistent with multiple sclerosis lesions

2025-02-08

Abstract excerpt

The cuprizone (CPZ) model is widely used for modeling demyelination in multiple sclerosis (MS) and for testing potential remyelination therapies. We integrated single-cell and spatial transcriptomics (ST) to fine map the spatial cellular and molecular responses during de and remyelination. ST revealed global demyelination and neuroinflammation in the brain beyond the corpus callosum, with region-specific differenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69231914-839d-5768-aac2-116157b13315
DOI: 10.1101/2025.02.07.637125

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial transcriptomics reveals heterogeneous cell–cell interactions among brain regions in a cuprizone model consistent with multiple sclerosis lesionsDOI 10.1101/2025.02.07.637125Read

A comparative transcriptomic analysis of mouse demyelination models and Multiple Sclerosis lesionsSemantic proximity Read

Single-cell Transcriptomics Analyses Revealed Specialized Microglial Subsets with Oligodendrocyte-like SignaturesSemantic proximity Read

Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesionsSemantic proximity Read

Human disease-specific cell signatures in non-lesional tissue in Multiple Sclerosis detected by single-cell and spatial transcriptomicsSemantic proximity Read

Single-Cell Multi-Omics Map of Cell Type–Specific Mechanistic Drivers of Multiple Sclerosis LesionsSemantic proximity Read

Identification of a microglia phenotype supportive of remyelination.Semantic proximity Read

Spatial cell type mapping of multiple sclerosis lesionsSemantic proximity Read

A single-cell multi-omics map of cell-type-specific mechanistic drivers of multiple sclerosis lesionsSemantic proximity Read

Microglial states determine lesion dynamics in multiple sclerosisSemantic proximity Read

An inducible genetic tool for tracking and manipulating specific microglial states in development and diseaseSemantic proximity Read

Lesion-remote astrocytes govern microglia-mediated white matter repairSemantic proximity Read

Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse modelSemantic proximity Read