Article

Soluble TREM2 induces microglia dysfunction and brain damage while cleavage-reduced TREM2 shows sustained microglia activation with enhanced myelination in the cuprizone model

2022-07-25

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells andmacrophages. Heterozygous loss-of-function mutations in TREM2, including mutations enhancing shedding form the cell-surface, have been associated with myelin/neuronal loss and neuroinflammation in neurodegenerative diseases like Alzheimer`s disease and Frontotemporal Dem...

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Literature Corpus work: f33f55d1-4753-55e9-9c09-d0f0fb6eab54
DOI: 10.21203/rs.3.rs-1852981/v1

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