Article

Selective Inactivation of Astrocytic Monoacylglycerol Lipase for Alzheimer’s Disease Therapy

2025-12-09

Abstract excerpt

Alzheimer’s disease (AD) is the leading cause of dementia in the elderly, yet effective therapies remain lacking. Here, we identify monoacylglycerol lipase (MAGL), the principal enzyme that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain, specifically in astrocytes as a promising therapeutic target for AD. APP transgenic (TG) mice with astrocyte-specific MAGL deletion (TG-aKO), but not neur...

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Literature Corpus work: d859e668-dec5-56fe-a990-80c9faba6d81
DOI: 10.64898/2025.12.04.692105

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