Article

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer’s Disease Revealed by Pharmacological and Genetic Microglial Depletion

2024-11-19

Abstract excerpt

Abnormal lipid metabolism in Alzheimer’s disease (AD) was first documented by Alois Alzheimer in his early observations of patients with a then unrecognized brain disease, which he noted was characterized by a significant presence of “adipose inclusions” or “lipoid granules”. Despite this early recognition, until recently the significance of abnormal lipid metabolism in AD has been largely overlooked by the scient...

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Literature Corpus work: e6088b41-ad0d-58e7-bb7b-1b54c2000d96
DOI: 10.1101/2024.11.18.624173

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