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Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

24 Jun 2021

Abstract excerpt

While the central nervous system compromises 2% of our body weight, it harbors up to 25% of the body's cholesterol. Cholesterol levels in the brain are tightly regulated for physiological brain function, but mounting evidence indicates that excessive cholesterol accumulates in Alzheimer's disease (AD), where it may drive AD-associated pathological changes. This seems especially relevant for late-onset AD, as...

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PMID: 34248607
DOI: 10.3389/fnagi.2021.690372

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