Article

Inhibition of Endocannabinoid Degradation in Astrocytes Reprograms Glial Reactivity and Prevents Seizure Sequelae

2026-02-07

Abstract excerpt

<h4>Background</h4> Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and is characterized by a pathological cascade of excitotoxicity that leads to neuroinflammation, progressive neuronal loss, and subsequent cognitive decline. Despite its prevalence, effective disease-modifying therapies remain lacking. Previous studies have demonstrated that the endocannabinoid system contributes to epilep...

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Literature Corpus work: eab29b66-09fd-501b-9602-530959c930a0
DOI: 10.64898/2026.02.04.703855

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