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Article

Molecular reorganization of endocannabinoid signalling in Alzheimer’s disease

31 Mar 2011

Abstract excerpt

Retrograde messengers adjust the precise timing of neurotransmitter release from the presynapse, thus modulating synaptic efficacy and neuronal activity. 2-Arachidonoyl glycerol, an endocannabinoid, is one such messenger produced in the postsynapse that inhibits neurotransmitter release upon activating presynaptic CB(1) cannabinoid receptors. Cognitive decline in Alzheimer's disease is due to synaptic failure in...

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PMID: 21459826
DOI: 10.1093/brain/awr046

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