Article

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

2020-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s Disease (AD) is characterized by the presence of β-Amyloid (Aβ) plaques, tau tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol transport protein, apolipoprotein E (apoE), is the most common genetic marker for sporadic AD. In vitro evidence suggests apoE links to Aβ production through nanoscale lipid compartments (also called lipid rafts), but...

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Literature Corpus work: 34ceb270-9188-57dd-ac93-2dc83649b5ec
DOI: 10.1101/2020.06.18.159632

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