Article

Overabundant endocannabinoids in neurons are detrimental to cognitive function

2024-09-17

Abstract excerpt

2-Arachidonoylglycerol (2-AG) is the most prevalent endocannabinoid involved in maintaining brain homeostasis. Previous studies have demonstrated that inactivating monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading 2-AG in the brain, alleviates neuropathology and prevents synaptic and cognitive decline in animal models of neurodegenerative diseases. However, we show that selectively inhib...

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Literature Corpus work: 0db929a9-64f8-53d7-a533-bdd48d24dc58
DOI: 10.1101/2024.09.17.613513

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