Neuroprotective function of astrocyte p75 ^NTR in Alzheimer’s Disease through regulation of cholesterol metabolism

Abstract excerpt

Reactive astrogliosis in Alzheimer’s Disease (AD) involves profound changes in the morphology, metabolism and secretion profile of astrocytes, but whether astrogliosis is beneficial or harmful, and under which conditions, remain open questions. Here we report an unexpected neuroprotective function of death receptor p75 NTR in astrocytes through its ability to regulate cholesterol metabolism. AD knock-in mice expr...

Topics

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• Alzheimer's disease research and treatments
• Amino Acid Enzymes and Metabolism
• Amyotrophic Lateral Sclerosis Research
• Astrocytes
• Neurodegenerative Diseases
• Neuroinflammation and Neurodegeneration Mechanisms
• Neuroscience and Neuropharmacology Research
• Phenotype

Identifiers and source

Literature Corpus work

f64171b9-cb86-513c-a8c7-ec2750a384f1

DOI

10.1101/2025.10.20.683521