Back to search

Article

PAM_16A activates the TMEM16A chloride channel by increasing its calcium affinity

2026-08-27

Abstract excerpt

<title>Abstract</title> <p>TMEM16A is a calcium-activated chloride channel, making it a promising therapeutic target for diseases characterised by impaired chloride influx, such as cystic fibrosis. While novel allosteric activators such as PAM_16A have been developed, their binding sites and mechanisms of action remain unknown. Here, I used a multi-tiered computational approach: Generative AI (Chai-1), MARTINI-3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d7b0ea97-ecec-5f07-88ba-6eaf31eafe12
DOI
10.21203/rs.3.rs-10481839/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PAM_16A activates the TMEM16A chloride channel by increasing its calcium affinityDOI 10.21203/rs.3.rs-10481839/v1
Molecular simulation assisted identification of Ca(2+) binding residues in TMEM16A.Semantic proximity
An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation.Semantic proximity
Deep Learning Dynamic Allostery of G-Protein-Coupled ReceptorsSemantic proximity
Deep Learning Dynamic Allostery of G-Protein-Coupled ReceptorsSemantic proximity
A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.Semantic proximity
Computational analysis of long-range allosteric communications in CFTRSemantic proximity
Niclosamide potentiates TMEM16A and induces vasoconstrictionSemantic proximity
Gating the pore of the calcium-activated chloride channel TMEM16A.Semantic proximity
Structural and Energetic Basis of Ca2+-Selective Permeation in the TRPV5 Channel.Semantic proximity
Mechanism of pore opening in the calcium-activated chloride channel TMEM16A.Semantic proximity
Generation of virtual populations for quantitative systems pharmacology through advanced sampling methodsSemantic proximity
A pan-positive allosteric modulator that mediates sustainable GPCR activationSemantic proximity
Select a neighboring publication to make it the new centre.