Article

Niclosamide potentiates TMEM16A and induces vasoconstriction

2023-08-02

Abstract excerpt

<h4>ABSTRACT</h4> The TMEM16A calcium-activated chloride channel is a promising therapeutic target for various diseases. Niclosamide, an anthelmintic medication, has been considered as a TMEM16A inhibitor for treating asthma and chronic obstructive pulmonary disease, but was recently found to possess broad-spectrum off-target effects. Here we show that, under physiological conditions, niclosamide acutely potentia...

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Literature Corpus work: c7eb1477-279c-5095-8598-ac681d19ac14
DOI: 10.1101/2023.07.31.551400

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