Article

Computational analysis of long-range allosteric communications in CFTR

2023-06-07

Abstract excerpt

Malfunction of the CFTR protein results in cystic fibrosis, one of the most common hereditary diseases. CFTR functions as an anion channel, the gating of which is controlled by long- range allosteric communications. Allostery also has direct bearings on CF treatment: the most effective CFTR drugs modulate its activity allosterically. Herein, we integrated Gaussian Network Model, Transfer Entropy, and Anisotropic N...

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Literature Corpus work: c1c87a99-f4b2-5bd0-8661-8b4b9ae0e7e4
DOI: 10.1101/2023.06.07.543997

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