Generation of virtual populations for quantitative systems pharmacology through advanced sampling methods

Abstract excerpt

<h4>ABSTRACT</h4> Virtual population (VPop) generation is a central component of quantitative systems pharmacology (QSP), involving the sampling of parameter sets that represent physiologically plausible patients and capture observed inter-individual variability in clinical outcomes. This approach poses challenges due to the high dimensionality and often non-identifiability nature of many QSP models. In this stud...

Topics

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• Biological Variation, Population
• Computer Simulation
• Drug Development
• Genomics
• Models, Biological
• Monoclonal and Polyclonal Antibodies Research
• Phenotype
• Proteomics

Identifiers and source

Literature Corpus work

6954b67c-ed22-5b88-8ef1-74b0b927831d

DOI

10.1101/2025.06.24.661262