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Article

Molecular simulation assisted identification of Ca(2+) binding residues in TMEM16A.

Journal of computer-aided molecular design - 1 Nov 2015

Pang Chun-Li, Yuan Hong-Bo, Cao Tian-Guang, Su Ji-Guo, Chen Ya-Fei, Liu Hui, Yu Hui, Zhang Hai-Ling, Zhan Yong, An Hai-Long, Han Yue-Bin

Abstract excerpt

Calcium-activated chloride channels (CaCCs) play vital roles in a variety of physiological processes. Transmembrane protein 16A (TMEM16A) has been confirmed as the molecular counterpart of CaCCs which greatly pushes the molecular insights of CaCCs forward. However, the detailed mechanism of Ca(2+) binding and activating the channel is still obscure. Here, we utilized a combination of computational and...

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PMID: 26481648
DOI: 10.1007/s10822-015-9876-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular simulation assisted identification of Ca(2+) binding residues in TMEM16A.PMID 26481648Read ↗

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