Article

Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors

2023-01-18

Abstract excerpt

G-protein-coupled receptors (GPCRs) are the largest superfamily of human membrane proteins and represent primary targets of ∼1/3 of currently marketed drugs. Allosteric modulators have emerged as more selective drug candidates compared with orthosteric agonists and antagonists. However, many X-ray and cryo-EM structures of GPCRs resolved so far exhibit negligible differences upon binding of positive and negative a...

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Literature Corpus work: ff1a1883-d5c5-53bf-a3fa-946987554343
DOI: 10.1101/2023.01.15.524128

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