Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of pore opening in the calcium-activated chloride channel TMEM16A.

Nature communications - 4 Feb 2021

Lam Andy K M, Dutzler Raimund

Abstract excerpt

The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. By combining electrophysiology and autocorrelation analysis, we investigated the mechanism of channel activation and the concurrent rearrangement of the gate in the narrow part of the pore. Features in the fluctuation characteristics of steady-state current indicate the sampling of intermediate conformations that are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Cations, Divalent
Share to Chlorides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Monte Carlo Method

Share to Patch-Clamp Techniques

Share to Poisson Distribution

Share to Protein Conformation, alpha-Helical

Source

Open in PubMed Open full text

Identifiers

PMID: 33542228
DOI: 10.1038/s41467-020-20788-8
PMCID: PMC7862263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of pore opening in the calcium-activated chloride channel TMEM16A.PMID 33542228Read ↗

Gating the pore of the calcium-activated chloride channel TMEM16A.Semantic proximity Read ↗

Independent activation of distinct pores in dimeric TMEM16A channels.Semantic proximity Read ↗

Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B.Semantic proximity Read ↗

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A.Semantic proximity Read ↗

Molecular simulation assisted identification of Ca(2+) binding residues in TMEM16A.Semantic proximity Read ↗

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.Semantic proximity Read ↗

An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation.Semantic proximity Read ↗

Localization of the activation gate of a voltage-gated Ca2+ channel.Semantic proximity Read ↗

A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.Semantic proximity Read ↗

Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating.Semantic proximity Read ↗

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.Semantic proximity Read ↗

Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.