Article
Gating the pore of the calcium-activated chloride channel TMEM16A.
Nature communications - 4 Feb 2021
Lam Andy K M, Rheinberger Jan, Paulino Cristina, Dutzler Raimund
Abstract excerpt
The binding of cytoplasmic Ca2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, we identified three hydrophobic residues at the intracellular entrance of the neck as constituents of this gate....
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