Article

A pan-positive allosteric modulator that mediates sustainable GPCR activation

2025-03-27

Abstract excerpt

Approximately 1/3 of all clinical drugs exert their therapeutic effects by modulating the activity of G protein-coupled receptors (GPCRs). Thus, there is a constant interest in finding novel ways to modulate GPCR activity. In this work, through a newly established Survival Pressure Selection (SPS) method for high-throughput screening of GPCR agonists, we discover that atazanavir functions as an agonist for GPR119....

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Literature Corpus work: 863b628c-0ab1-5e14-9a38-df23b0333baf
DOI: 10.1101/2025.03.24.645127

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