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Article

Structural and Energetic Basis of Ca2+-Selective Permeation in the TRPV5 Channel.

Journal of chemical information and modeling - 11 May 2026

Meng Yuxin, Lin Yuhong, Shen Yong

Abstract excerpt

TRPV5 is a calcium-selective epithelial ion channel that is essential for renal Ca2+ reabsorption and systemic calcium homeostasis. Despite recent structural advances, the energetic basis and coordinated contributions of the three selectivity-filter residues (D542, T539, and N572/I575) to Ca2+ selectivity remain unresolved. Here, we combine absolute and relative binding free-energy calculations (ABFE/RBFE), pore...

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Identifiers

PMID: 42026841
DOI: 10.1021/acs.jcim.6c00021

Genes

TRPV5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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