Article

Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors

2023-02-20

Abstract excerpt

<title>Abstract</title> <p>G-protein-coupled receptors (GPCRs) are the largest superfamily of human membrane proteins and represent primary targets of ~ 1/3 of currently marketed drugs. Allosteric modulators have emerged as more selective drug candidates compared with orthosteric agonists and antagonists. However, many X-ray and cryo-EM structures of GPCRs resolved so far exhibit negligible differences upon bindi...

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Literature Corpus work: 4e3261d3-b809-5974-923a-5365930401a6
DOI: 10.21203/rs.3.rs-2543463/v1

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