A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.

doi:10.7554/eLife.02772

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Article

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.

eLife - 30 Jun 2014

Tien Jason, Peters Christian J, Wong Xiu Ming, Cheng Tong, Jan Yuh Nung, Jan Lily Yeh, Yang Huanghe

Abstract excerpt

TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological processes such as the secretions of airway epithelia and exocrine glands, the contraction of smooth muscles, and the excitability of neurons. Notwithstanding intense interest in the mechanism behind TMEM16A-CaCC calcium-dependent gating, comprehensive surveys to identify and characterize potential calcium sensors of this channel...

Topics

Alanine
Amino Acid Sequence
Animals
Anoctamin-1
Binding Sites
Calcium
Calmodulin
Chloride Channels
Cysteine
Drosophila
Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Green Fluorescent Proteins

HEK293 Cells

Humans

Ions

Mice

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 24980701
DOI: 10.7554/eLife.02772
PMCID: PMC4112547

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