Article

A tight inducible model for oncogene function and drug testing

2026-07-31

Abstract excerpt

<title>Abstract</title> <p> Precise control of oncogene expression is crucial for advancing tumor biology research and therapeutic testing. To address limitations of current systems, we developed a novel, tightly regulated, genome-integratable inducible expression platform, based on an optimized cumate gene-switch system. By engineering a KRAB-fused, NLS-enhanced CymR repressor (CSwitch-Silencer), a CpG-free hyb...

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Literature Corpus work: d7215560-8d46-56a7-a05e-7556e2a35b2c
DOI: 10.21203/rs.3.rs-9929991/v1

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