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Programmable <i>in vivo</i> CRISPR activation elucidates the oncogenic and immunosuppressive role of MYC in lung adenocarcinoma

2021-12-09

Abstract excerpt

Conventional genetically engineered mouse models (GEMMs) are time consuming, laborious and offer limited spatio-temporal control. Here, we describe the development of a streamlined platform for in vivo gene activation using CRISPR activation (CRISPRa) technology. Unlike conventional GEMMs, our model system allows for flexible, sustained and timed activation of one or more target genes using single or pooled lenti...

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Identifiers and source

Literature Corpus work
7f89664d-068f-5f87-8c9e-42220d57ad4f
DOI
10.1101/2021.12.09.471859
Open publication

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Programmable <i>in vivo</i> CRISPR activation elucidates the oncogenic and immunosuppressive role of MYC in lung adenocarcinomaDOI 10.1101/2021.12.09.471859
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