Article

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

2022-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Single nucleotide variants (SNVs) comprise the majority of cancer-associated genetic changes and can have diverse effects on protein function. Despite a comprehensive catalogue of SNVs across human cancers, little is known about their impact on tumor initiation and progression. To enable the functional interrogation of cancer-associated SNVs, we developed a murine system for temporal and regulat...

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Literature Corpus work: e50dfa72-a0c7-5982-b233-972c2b3ee915
DOI: 10.1101/2022.08.03.502708

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