Article

KLIPP - a precision CRISPR approach to target structural variant junctions in cancer

2023-05-12

Abstract excerpt

Current cancer therapies typically give rise to dose-limiting normal tissue toxicity. We have developed KLIPP, a precision cancer approach that specifically kills cancer cells using CRISPR/Cas9 technology. The approach consists of guide RNAs that target cancer-specific structural variant junctions to nucleate two parts of a dCas9-conjugated endonuclease, Fok1, leading to its activation. We show that KLIPP causes i...

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Literature Corpus work: d689faaa-afe2-5127-81af-9f9ef9abc94e
DOI: 10.1101/2023.05.10.540176

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