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Article

Scalable recombinase-based gene expression cascades.

Nature communications - 11 May 2021

Kim Tackhoon, Weinberg Benjamin, Wong Wilson, Lu Timothy K

Abstract excerpt

Temporal modulation of the expression of multiple genes underlies complex complex biological phenomena. However, there are few scalable and generalizable gene circuit architectures for the programming of sequential genetic perturbations. Here, we describe a modular recombinase-based gene circuit architecture, comprising tandem gene perturbation cassettes (GPCs), that enables the sequential expression of multiple...

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Identifiers

PMID: 33976199
DOI: 10.1038/s41467-021-22978-4
PMCID: PMC8113245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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