Article

Concerted neuron-astrocyte gene expression declines in aging and schizophrenia

2024-01-08

Abstract excerpt

Human brains vary across people and over time; such variation is not yet understood in cellular terms. Here we describe a striking relationship between people’s cortical neurons and cortical astrocytes. We used single-nucleus RNA-seq to analyze the prefrontal cortex of 191 human donors ages 22-97 years, including healthy individuals and persons with schizophrenia. Latent-factor analysis of these data revealed that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6fe1896-00b1-5725-b176-bd26ce82256b
DOI: 10.1101/2024.01.07.574148

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Concerted neuron-astrocyte gene expression declines in aging and schizophreniaDOI 10.1101/2024.01.07.574148Read

A concerted neuron-astrocyte program declines in ageing and schizophrenia.Semantic proximity Read

Single-cell multi-cohort dissection of the schizophrenia transcriptome.Semantic proximity Read

Inter-individual variation of cellular and gene-expression properties of the human striatumSemantic proximity Read

Single-cell multi-cohort dissection of the schizophrenia transcriptomeSemantic proximity Read

Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilienceSemantic proximity Read

Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programsSemantic proximity Read

Single-nuclei transcriptomics of schizophrenia prefrontal cortex primarily implicates neuronal subtypesSemantic proximity Read

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s diseaseSemantic proximity Read

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s diseaseSemantic proximity Read

An Integrative Analysis Identified Schizophrenia-Associated Brain Cell Types and Gene Expression ChangesSemantic proximity Read

Genetic identification of brain cell types underlying schizophrenia.Semantic proximity Read

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivitySemantic proximity Read