Article
Genetic identification of brain cell types underlying schizophrenia.
Nature genetics - 1 Jun 2018
Skene Nathan G, Bryois Julien, Bakken Trygve E, Breen Gerome, Crowley James J, Gaspar Héléna A, Giusti-Rodriguez Paola, Hodge Rebecca D, Miller Jeremy A, Muñoz-Manchado Ana B, O'Donovan Michael C, Owen Michael J, Pardiñas Antonio F, Ryge Jesper, Walters James T R, Linnarsson Sten, Lein Ed S, Sullivan Patrick F, Hjerling-Leffler Jens
Abstract excerpt
With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia have not converged on findings that can be confidently used for precise experimental modeling. By applying knowledge of the cellular taxonomy of the brain from single-cell RNA sequencing, we evaluated whether the genomic loci implicated in schizophrenia map onto specific brain cell types. We found that the...
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