Article

Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs

2025-01-28

Abstract excerpt

Astrocytes participate in neuronal synaptic programs that are enriched for genetic associations in schizophrenia and autism spectrum disorders (ASD). To better understand how these co-regulated cellular programs are induced during early neuronal development, we studied astrocytes and iPSC-derived neurons in co-cultures and mono-cultures at 16 time points spanning 0.5 hours to 8 days. We found that upregulation in...

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Literature Corpus work: a709e8d5-b1f4-5aa7-afe5-e5f9dc98baeb
DOI: 10.1101/2025.01.28.635252

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