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Article

A concerted neuron-astrocyte program declines in ageing and schizophrenia.

Nature - 1 Mar 2024

Ling Emi, Nemesh James, Goldman Melissa, Kamitaki Nolan, Reed Nora, Handsaker Robert E, Genovese Giulio, Vogelgsang Jonathan S, Gerges Sherif, Kashin Seva, Ghosh Sulagna, Esposito John M, Morris Kiely, Meyer Daniel, Lutservitz Alyssa, Mullally Christopher D, Wysoker Alec, Spina Liv, Neumann Anna, Hogan Marina, Ichihara Kiku, Berretta Sabina, McCarroll Steven A

Abstract excerpt

Human brains vary across people and over time; such variation is not yet understood in cellular terms. Here we describe a relationship between people's cortical neurons and cortical astrocytes. We used single-nucleus RNA sequencing to analyse the prefrontal cortex of 191 human donors aged 22-97 years, including healthy individuals and people with schizophrenia. Latent-factor analysis of these data revealed that,...

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Identifiers

PMID: 38448582
DOI: 10.1038/s41586-024-07109-5
PMCID: PMC10954558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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