Article

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

2022-12-21

Abstract excerpt

<title>Abstract</title> <p>Astrocytes play a critical role in brain homeostasis and normal functions but their changes along the spatiotemporal progression of Alzheimer’s disease (AD) neuropathology remain largely unknown. Here we performed single-nucleus RNA-sequencing on brain regions along the stereotypical progression of AD pathology from donors ranging the entire normal aging-AD continuum comprising 628,943...

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Literature Corpus work: 08837ead-a872-5ad2-9801-076a53d2405b
DOI: 10.21203/rs.3.rs-2261934/v1

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