Article

Histone Tail Electrostatics Modulate E2-E3 Enzyme Dynamics: A Gateway to Regulate Ubiquitination Machinery

2022-08-27

Abstract excerpt

BRCA1 (BReast Cancer-Associated protein 1), a human tumor suppressor, plays a key role in genome stability and DNA repair. Heterodimerization of BRCA1 with BARD1 is important for its stability, maximal Ub ligase (E3) activity and cooperative activation of UbcH5c (E2). Recent studies demonstrate the importance of ubiquitination of the nucleosomal H2A C-terminal tail by BRCA1/BARD1-UbcH5c (E3-E2) in which its mutati...

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Literature Corpus work: b0f05ba4-d02d-58c4-bea1-bb3cf4954bd4
DOI: 10.1101/2022.08.27.505537

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