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Article

Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.

Molecular cell - 1 Jul 2021

Dai Linchang, Dai Yaxin, Han Jinhua, Huang Yan, Wang Longge, Huang Jun, Zhou Zheng

Abstract excerpt

The BRCA1-BARD1 complex directs the DNA double-strand break (DSB) repair pathway choice to error-free homologous recombination (HR) during the S-G2 stages. Targeting BRCA1-BARD1 to DSB-proximal sites requires BARD1-mediated nucleosome interaction and histone mark recognition. Here, we report the cryo-EM structure of BARD1 bound to a ubiquitinated nucleosome core particle (NCPUb) at 3.1 Å resolution and illustrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34102105
DOI: 10.1016/j.molcel.2021.05.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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