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Article

Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.

Nature - 1 Aug 2021

Hu Qi, Botuyan Maria Victoria, Zhao Debiao, Cui Gaofeng, Mer Elie, Mer Georges

Abstract excerpt

The BRCA1-BARD1 tumour suppressor is an E3 ubiquitin ligase necessary for the repair of DNA double-strand breaks by homologous recombination1-10. The BRCA1-BARD1 complex localizes to damaged chromatin after DNA replication and catalyses the ubiquitylation of histone H2A and other cellular targets11-14. The molecular bases for the recruitment to double-strand breaks and target recognition of BRCA1-BARD1 remain...

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Identifiers

PMID: 34321665
DOI: 10.1038/s41586-021-03716-8
PMCID: PMC8680157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.PMID 34321665Read ↗

Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.Semantic proximity Read ↗

The BRCA1/BARD1 ubiquitin ligase and its substrates.Semantic proximity Read ↗

Histone H3 Orchestrates the Ubiquitination of Nucleosomal H2A by BRCA1/BARD1-UbcH5c ComplexSemantic proximity Read ↗

RETRACTED: Structural analysis of BRCA1 reveals modification hotspot.Semantic proximity Read ↗

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.Semantic proximity Read ↗

BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.Semantic proximity Read ↗

Functional Link between BRCA1 and BAP1 through Histone H2A, Heterochromatin and DNA Damage Response.Semantic proximity Read ↗

Structure of the human Bre1 complex bound to the nucleosomeSemantic proximity Read ↗

Structure and function of the RAD51B–RAD51C–RAD51D–XRCC2 tumour suppressorSemantic proximity Read ↗

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.Semantic proximity Read ↗

BRCA1-dependent and independent functions of BARD1.Semantic proximity Read ↗

BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export.Semantic proximity Read ↗

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