Article

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

2024-01-03

Abstract excerpt

<h4>Abstracts</h4> The DNA damage repair regulatory protein RNF168, a monomeric RING-type E3 ligase, plays a crucial role in regulating cell fate and DNA repair by specific and efficient ubiquitination of the adjacent Lys13 and Lys15 sites at the H2A N-terminal tail. However, understanding how RNF168 coordinates with its cognate E2 enzyme UbcH5c to ubiquitinate H2AK13/15 site-specifically has long been hampered b...

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Literature Corpus work: 84e67841-7e93-5269-8d60-e8a1c621e2e9
DOI: 10.1101/2024.01.02.573964

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