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Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses

6 Sept 2022

Abstract excerpt

Inhibition of host DNA damage response (DDR) is a common mechanism used by viruses to manipulate host cellular machinery and orchestrate viral life cycles. Epstein-Barr virus tegument protein BKRF4 associates with cellular chromatin to suppress host DDR signaling, but the underlying mechanism remains elusive. Here, we identify a BKRF4 histone binding domain (residues 15-102, termed BKRF4-HBD) that can accumulate...

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PMID: 36067323
DOI: 10.1073/pnas.2203782119

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