Article

<i>De novo</i> cancer mutations frequently associate with recurrent chromosomal abnormalities during long-term human pluripotent stem cell culture

2024-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Human pluripotent stem cells (hPSC) are pivotal in regenerative medicine, yet their in vitro expansion often leads to genetic abnormalities, raising concerns about their safety in clinical applications. This study analyzed ten human embryonic stem cell lines across multiple passages to elucidate the dynamics of chromosomal abnormalities and single nucleotide variants (SNVs) in 380 cancer-relate...

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Literature Corpus work: d66d63f4-722e-5b1a-82ba-ec604fe7b0a1
DOI: 10.1101/2024.07.01.601640

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