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De Novo Cancer Mutations Frequently Associate with Recurrent Chromosomal Abnormalities during Long-Term Human Pluripotent Stem Cell Culture.

Cells - 21 Aug 2024

Al Delbany Diana, Ghosh Manjusha S, Krivec Nuša, Huyghebaert Anfien, Regin Marius, Duong Mai Chi, Lei Yingnan, Sermon Karen, Olsen Catharina, Spits Claudia

Abstract excerpt

Human pluripotent stem cells (hPSCs) are pivotal in regenerative medicine, yet their in vitro expansion often leads to genetic abnormalities, raising concerns about their safety in clinical applications. This study analyzed ten human embryonic stem cell lines across multiple passages to elucidate the dynamics of chromosomal abnormalities and single-nucleotide variants (SNVs) in 380 cancer-related genes. Prolonged...

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Identifiers

PMID: 39195283
DOI: 10.3390/cells13161395
PMCID: PMC11353044

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